Zonisamide: The Arizona Experience
نویسندگان
چکیده
منابع مشابه
Zonisamide clinical trials: European experience
European clinical trials of zonisamide as adjunctive therapy for refractory partial seizures included a 12-week double-blind, placebo-controlled study and a 15-month open-label extension study. In the double-blind study, patients (n = 144) were randomized to placebo or zonisamide (400 mg QD) after baseline evaluation. Patients completing the double-bind study (n = 115) continued on open-label z...
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The current overview of zonisamide use and effectiveness is based on both a long-term prospective postmarketing survey and current zonisamide use at the Saitama Medical College, Department of Neuropsychiatry. Survey data, which were collected from individual physicians and 23 survey groups throughout Japan, assessed the effectiveness of zonisamide in 1631 patients. Zonisamide was highly effecti...
متن کاملZonisamide overview of the United States experience
Although established antiepilepsy drugs (AEDs) are efficacious and new drugs have become available to treat patients with epilepsy, at least 30% of all patients remain refractory to available treatment.1 Continued efforts to identify and develop new compounds for the treatment of epilepsy motivate all concerned because of the plight of so many patients. In the following sections, data are provi...
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Dr. Yamauchi has pointed out that those patients receiving polytherapy did not do as well as those receiving zonisamide monotherapy. He backed up his observations with blood levels of zonisamide for all the groups. I believe that his observations suggest that the zonisamide dose should be higher, unless the side effects become limiting. As this was a retrospective study, detailed analyses were ...
متن کاملZonisamide – a review of experience and use in partial seizures
Zonisamide is a modern antiepileptic drug (AED) that is distinguished from other AEDs by its unique structure and broad mechanistic profile. Preclinical studies have reported a range of potential mechanisms of action for zonisamide, such as blocking voltage-gated sodium channels, reduction of T-type calcium channel currents, and enhancement of gamma-aminobutyric acid (GABA)-mediated inhibition,...
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ژورنال
عنوان ژورنال: American Journal of Pharmacology and Toxicology
سال: 2007
ISSN: 1557-4962
DOI: 10.3844/ajptsp.2007.60.64